Abstract: Background　Obesity adds to potential for chronic diseases.Diet interventions are a kind of important approach for obesity prevention and treatment，among which fast diet may be a novel way.However，previous studies can not provide very convincing evidence about the effect of fast diet on obesity due to small sample size and inadequate analyses of action mechanism of fast diet and dose-effect relationship.Objective　To discuss the effects of fast diet on metabolic changes in overweight patients.Methods　We enrolled 86 cases from an enterprise during December 2016 to January 2017.All of them were overweight（BMI≥24.0 kg/m2） initially found by a health check-up in Tianjin Haibin Hospital.They received a 60-day fast diet therapy，during the intervention period，they ate normally for five days per week according to personal preference，but on the other discontinuous two days，they restricted their calorie intake to 600 kcal per day.Metabolism-related indicators at the day prior to the intervention and at the last day of the intervention were collected.Results　 80 patients completed the intervention.Compared with baseline，after intervention，diastolic blood pressure，body weight and body fat percentage decreased significantly（P<0.05），but systolic blood pressure and heart rate only changed insignificantly（P>0.05）；LDL-C increased significantly（P<0.05），while TC，TG，and HDL-C showed little changes（P>0.05）；fructosamine and HbA1c decreased significantly（P<0.05）；Glu showed insignificant changes（P>0.05），but 1 hPG and 2 hPG decreased significantly（P<0.05） showed by the 75 g OGTT；fasting insulin decreased obviously（P<0.05），but 1-hour and 2-hour postprandial insulin presented minor changes（P>0.05） found by insulin response test.Conclusion　Fast diet is an effective weight loss intervention for overweight people，which can obviously improve the physiological stress state and insulin sensitivity，and reduce postprandial blood sugar as well as the risk of developing overweight-related complications.

Key words: Obesity；Overweight；Diet, reducing；Fast diet；Metabolic syndrome X

摘要： 背景　肥胖可增加多种慢性病的发生风险，饮食干预是防治肥胖的重要措施之一，其中轻断食模式可能是防治肥胖的一条新途径。但既往研究样本量较小，关于作用机制和量效关系的分析不足，尚不能提供充分的科学依据。目的　探讨轻断食模式对超重者代谢作用的影响。方法　2016年12月—2017年1月，选取在天津海滨医院接受体检的某企业员工86例进行轻断食模式干预，均为初次检出超重者（BMI≥24.0 kg/m2）。轻断食模式干预方法为：每周中不连续的2 d每日只摄入600 kcal能量，余5 d根据个人饮食习惯自由饮食，干预时间为60 d。分别于干预实施前1日和干预周期最后1日，检测受试者代谢相关指标。结果　80例超重者按要求完成了轻断食模式干预。干预后受试者舒张压、体质量、体脂百分比低于干预前（P<0.05），收缩压、心率与干预前无差异（P>0.05）。干预后受试者低密度脂蛋白胆固醇高于干预前（P<0.05），总胆固醇、三酰甘油、高密度脂蛋白胆固醇与干预前无差异（P>0.05）。干预后受试者果糖胺、糖化血红蛋白低于干预前（P<0.05）。糖耐量试验显示，干预后受试者空腹血糖与干预前无差异（P>0.05），餐后1 h血糖、餐后2 h血糖低于干预前（P<0.05）。胰岛素释放试验显示，干预后受试者空腹胰岛素低于干预前（P<0.05），餐后1 h胰岛素、餐后2 h胰岛素与干预前无差异（P>0.05）。结论　轻断食模式是超重者减重的有效方法，可以明显改善超重者的机体应激状态，提高胰岛素敏感性、降低餐后血糖，有助于减少超重相关并发症的发生。

关键词: 肥胖症；超重；膳食, 减重；轻断食；代谢综合征X