Mutations in the S Gene Region of Hepatitis B Virus and Postoperative Survival in Patients with Hepatitis B Virus-associated Hepatocellular Carcinoma
1.The Fourth Hospital of Hebei Medical University,Shijiazhuang 050011,China
2.First Hospital of Qinhuangdao,Qinhuangdao 066000,China
3.Peking Union Medical College Hospital,Beijing 100032,China
4.Hebei Medical University,Shijiazhuang 050017,China
*Corresponding authors:ZHANG Weiguo,Associate professor;E-mail:hebzhang@yeah.net
ZHANG Ruixing,Professor;E-mail:zrx@ medmail.com.cn
WU Chensi,ZHAO Yue,WU Jianhua, et al. Mutations in the S Gene Region of Hepatitis B Virus and Postoperative Survival in Patients with Hepatitis B Virus-associated Hepatocellular Carcinoma [J]. Chinese General Practice, 2019, 22(15): 1807-1811. DOI: 10.12114/j.issn.1007-9572.2019.00.156.
吴忱思,赵乐,吴建华等. 乙型肝炎病毒S区基因突变对乙型肝炎病毒相关性肝细胞癌患者预后的影响研究[J]. 中国全科医学, 2019, 22(15): 1807-1811. DOI: 10.12114/j.issn.1007-9572.2019.00.156.
[1]MCGLYNN K A,PETRICK J L,LONDON W T.Global epidemiology of hepatocellular carcinoma:an emphasis on demographic and regional variability[J].Clin Liver Dis,2015,19(2):223-238.DOI:10.1016/j.cld.2015.01.001.
[2]吕桂帅,陈磊,王红阳.我国肝癌研究的现状与前景[J].生命科学,2015,27(3):237-248.DOI:10.13376/j.cbls/2015034.
LYU G S,CHEN L,WANG H Y.Research progress and prospect of liver cancer in China[J].Chinese Bulletin of Life Sciences,2015,27(3):237-248.DOI:10.13376/j.cbls/2015034.
[3]WANG C J,ZHANG F B,FAN H Y,et al.Sequence polymorphisms of mitochondrial D-loop and hepatocellular carcinoma outcome[J].Biochem Biophys Res Commun,2011,406(3):493-496.DOI:10.1016/j.bbrc.2011.02.088.
[4]HIRAOKA A,KAWAMURA T,AIBIKI T,et al.Prognosis and therapy for ruptured hepatocellular carcinoma:problems with staging and treatment strategy[J].Eur J Radiol,2015,84(3):366-371.DOI:10.1016/j.ejrad.2014.11.038.
[5]TR PO C,CHAN H L Y,LOK A.Hepatitis B virus infection[J].Lancet,2014,384(9959):2053-2063.DOI:10.1016/s0140-6736(14)60220-8.
[6]POLLICINO T,CACCIOLA I,SAFFIOTI F,et al.Hepatitis B virus preS/S gene variants:pathobiology and clinical implications[J].J Hepatol,2014,61(2):408-417.DOI:10.1016/j.jhep.2014.04.041.
[7]LU F M,ZHUANG H.Management of hepatitis B in China[J].Chin Med J,2009,122(1):3-4.
[8]郝华,杨俊英,侯临平,等.乙型肝炎病毒基因分型研究新进展[J].中国实用医刊,2016,43(16):125-128.DOI:10.3760/cma.j.issn.1674-4756.2016.16.050.
HAO H,YANG J Y,HOU L P,et al.Research advances of hepatitis B virus genotypes[J].Chinese Journal of Practical Medicine,2016,43(16):125-128.DOI:10.3760/cma.j.issn.1674-4756.2016.16.050.
[9]LI H M,WANG J Q,WANG R,et al.Hepatitis B virus genotypes and genome characteristics in China[J].World J Gastroenterol,2015,21(21):6684-6697.DOI:10.3748/wjg.v21.i21.6684.
[10]ZHANG X,DING H G.Key role of hepatitis B virus mutation in chronic hepatitis B development to hepatocellular carcinoma[J].World J Hepatol,2015,7(9):1282-1286.DOI:10.4254/wjh.v7.i9.1282.
[11]LAMONTAGNE R J,BAGGA S,BOUCHARD M J.Hepatitis B virus molecular biology and pathogenesis[J].Hepatoma Res,2016,2(7):163.DOI:10.20517/2394-5079.2016.05.
[12]董绍斌,王富珍,张爽,等.原发性肝癌合并HBV感染者的HBV基因特征分析[J].中华实验和临床病毒学杂志,2017,31(2):92-97.DOI:10.3760/CMA.J.ISSN.1003-9279.2017.02.002.
DONG S B,WANG F Z,ZHANG S,et al.Sequence analysis of HBV in primary hepatomas patients infected with HBV[J].Chinese Journal of Experimental and Clinical Virology,2017,31
(2):92-97.DOI:10.3760/CMA.J.ISSN.1003-9279.2017.02.002.
[13]郑丹,邓伟,黄天壬,等.广西壮族自治区肝癌高发区HBV基因型、BCP/前C区突变与肝癌相关性的研究[J].中华流行病学杂志,2015,36(7):725-729.DOI:10.3760/cma.j.issn.0254-6450.2015.07.013.
ZHENG D,DENG W,HUANG T R,et al.Relationship between hepatitis B virus genotype,BCP/Pre-C region mutations and risk of hepatocellular carcinoma in Guangxi Zhuang Autonomous Region[J].Chinese Journal of Epidemiology,2015,36(7):725-729.DOI:10.3760/cma.j.issn.0254-6450.2015.07.013.
[14]AN P,XU J H,YU Y Y,et al.Host and viral genetic variation in HBV-related hepatocellular carcinoma[J].Front Genet,2018,9:261.DOI:10.3389/fgene.2018.00261.
[15]HATAZAWA Y,YANO Y,OKADA R,et al.Quasispecies variant of pre-S/S gene in HBV-related hepatocellular carcinoma with HBs antigen positive and occult infection[J].Infect Agents Cancer,2018,13:7.DOI:10.1186/s13027-018-0179-4.
[16]石仁芳,吴继周,万裴琦,等.广西肝癌高发区乙型肝炎病毒基本核心启动子区A1762T/G1764A双突变对肝癌家族聚集的影响[J].中国全科医学,2015,18(5):530-534.DOI:10.3969/j.issn.1007-9572.2015.05.011.
SHI R F,WU J Z,WAN P Q,et al.Effect of double mutation of basal core promoter A1762T/G1764A of hepatitis B virus on familial aggregation of primary liver cancer in area of Guangxi with high primary liver cancer incidence[J].Chinese General Practice,2015,18(5):530-534.DOI:10.3969/j.issn.1007-9572.2015.05.011.
[17]MAINI M K,GEHRING A J.The role of innate immunity in the immunopathology and treatment of HBV infection[J].J Hepatol,2016,64(1 Suppl):S60-70.DOI:10.1016/j.jhep.2016.01.028.
[18]SUGIYAMA M,MIZOKAMI M.Hepatitis B virus genotype and the mutation related to clinical outcome[J].Nippon Rinsho,2015,73(Suppl 9):377-381.
[19]荣义辉,辛绍杰.乙型肝炎病毒S区基因变异研究进展[J].肝脏,2013,18(11):779-781.DOI:10.14000/j.cnki.issn.1008-1704.2013.11.001.
[20]YE Q,SHANG S Q,LI W.A new vaccine escape mutant of hepatitis B virus causes occult infection[J].Hum Vaccin Immunother,2015,11(2):407-410.DOI:10.4161/21645515.2014.994461.
[21]STICCHI L,CALIGIURI P,CACCIANI R,et al.Epidemiology of HBV S-gene mutants in the Liguria Region,Italy:implications for surveillance and detection of new escape variants[J].Hum Vaccin Immunother,2013,9(3):568-571.
[22]CHOI Y M,LEE S Y,KIM B J.Naturally occurring hepatitis B virus reverse transcriptase mutations related to potential antiviral drug resistance and liver disease progression[J].World J Gastroenterol,2018,24(16):1708-1724.DOI:10.3748/wjg.v24.i16.1708.
[23]WANG L H,HUANG W Y,LAI M D,et al.Aberrant cyclin A expression and centrosome overduplication induced by hepatitis B virus pre-S2 mutants and its implication in hepatocarcinogenesis[J].Carcinogenesis,2012,33(2):466-472.DOI:10.1093/carcin/bgr296.
[24]GWAK G Y,LEE D H,MOON T G,et al.The correlation of hepatitis B virus pre-S mutation with cellular oxidative DNA damage in hepatocellular carcinoma[J].Hepatogastroenterology,2008,55(88):2028-2032.
[25]李萍,王丽,胡蓉,等.血清纤维化标志物和肝功能指标在慢性乙型肝炎患者肝纤维化诊断中的价值[J].疑难病杂志,2017,16(6):575-578,583. DOI:10.3969/j.issn.1671-6450.2017.06.009.
LI P,WANG L,HU R,et al.The applications of serum fibrosis index and liver function in patients with chronic hepatitis B and its diagnostic value in liver fibrosis[J]. Chinese Journal of Difficult and Complicated Cases,2017,16(6):575-578,583. DOI:10.3969/j.issn.1671-6450.2017.06.009.