Abstract: Objective　To explore the risk factors of type 2 diabetes mellitus（T2DM） complicated with metabolic inflammatory syndrome（MIS）.Methods　We enrolled 1 014 T2DM inpatients from Department of Endocrinology，Affiliated Hospital of Liaoning University of Traditional Chinese Medicine from March to October 2016，including 852 with MIS and 162 without（MIS was identified by the corresponding diagnostic criteria）.We collected their baseline clinical data and laboratory findings.Logistic regression analysis was used to explore the risk factors of T2DM combined with MIS.Results　The average body mass index，waist circumference，fasting C-peptide，2-hour postprandial C-peptide，triacylglycerol，total cholesterol and C-reactive protein levels，and prevalence rate of diabetic peripheral neuropathy differed significantly between the two groups（P<0.05），while gender，the average age，duration of T2DM with MIS，glycosylated hemoglobin，low-density lipoprotein cholesterol，prevalence rates of diabetic nephropathy and diabetic retinopathy did not（P>0.05）.Multivariate Logistic regression analysis found that increased CRP and BMI were risk factors for T2DM with MIS（P<0.05）.Conclusion　Increased CRP and BMI are risk factors for T2DM with MIS.The awareness of this is helpful for early screening，prevention，treatment，and prognostic improvement of T2DM.

Key words: Metabolic inflammatory syndrome；Diabetes, type 2；Obesity

摘要： 目的　探讨2型糖尿病（T2DM）合并代谢性炎症综合征（MIS）的危险因素。方法　选取于2016年3—10月在辽宁中医药大学附属医院内分泌科住院的T2DM患者1 014例为研究对象。根据MIS诊断标准，将患者分为非MIS组（n=162）和MIS组（n=852）。收集患者一般资料和实验室检查结果，采用Logistic回归分析探讨T2DM合并MIS的危险因素。结果　两组患者体质指数（BMI）、腰围（WC）、空腹C肽（FCP）、餐后2 h C肽（2 hCP）、三酰甘油（TG）、总胆固醇（TC）、C反应蛋白（CRP）、并发糖尿病周围神经病变的比例比较，差异有统计学意义（P<0.05）；两组患者性别、年龄、病程、糖化血红蛋白（HbA1c）、低密度脂蛋白胆固醇（LDL-C）、并发糖尿病肾病、糖尿病视网膜病变的比例比较，差异无统计学意义（P>0.05）。多因素Logistic回归分析结果显示，高水平CRP、高BMI是T2DM合并MIS的危险因素（P<0.05）。结论　高水平CRP、高BMI是T2DM合并MIS的危险因素，了解其危险因素有利于早期筛查和防治，改善T2DM患者预后。

关键词: 代谢性炎症综合征, 糖尿病, 2型, 肥胖症