Abstract: Objective　To analyze the clinical features of cryptogenic multifocal ulcerous stenosing enteritis（CMUSE） and to provide a reference for clinical diagnosis and treatment.Methods　A case of CMUSE admitted to Beijing Shijitan Hospital，Capital Medical University in February 2012 was retrieved.And related databases were searched to collect case reports of CMUSE.The general data，clinical manifestations，laboratory tests，imaging examinations，endoscopy and pathology data，treatment methods and outcomes of the patients were summarized and analyzed.Results　Twenty-two cases were collected，comprising 18 confirmed cases and 4 suspected cases.There were 10 males and 12 females with a median age of 32 years.The median time from disease onset to diagnosis was 3 years.Common clinical symptoms included abdominal pain（20 cases），bloating（10 cases），nausea and vomiting（8 cases），black stool（7 cases） and so on.Laboratory tests showed 12 cases of hypoalbuminemia and 11 cases of positive occult blood.There were 11 cases undergoing enteroscopy，9 cases undergoing capsule endoscopy and 8 cases undergoing double contrast radiography of small intestine，and positive findings were found in all cases.Twelve cases received surgical treatment，and seven cases relapsed after operation.Twelve cases received glucocorticoid treatment，among which eight cases experienced remission，and the treatment was ineffective in four cases.One case was responsive to infliximab treatment.Conclusion　CMUSE is a rare disease characterized by multiple small intestine superficial ulcers and intestinal lumen stenosis.Capsule endoscopy and double-balloon enteroscopy are important for the diagnosis of the disease.Hormone treatment is the first-line therapy.Endoscopic balloon dilation is used for treatment，and other treatments include nutritional support and surgery.

Key words: Enterocolitis；Cryptogenic multifocal ulcer stenosis enteritis；Capsule endoscopes；Glucocorticoids；Symptoms &, signs

摘要： 目的　分析隐源性多灶性溃疡狭窄性小肠炎（CMUSE）临床特征，为临床诊治提供参考。方法　结合首都医科大学附属北京世纪坛医院2012年2月收治的1例CMUSE病例，检索中英文数据库，收集确诊或疑诊为CMUSE的个案报道，并对病例的一般资料、临床表现、实验室检查、影像学检查、内镜检查、病理检查、治疗方法与转归进行总结分析。结果　共收集22例患者，确诊18例，疑诊4例；男10例，女12例；中位年龄为32岁，自发病至确诊的中位时间为3年。常见的临床表现有腹痛（20例），腹胀（10例），恶心、呕吐（8例），便血、黑便（7例）等；实验室检查低清蛋白血症12例，便隐血试验阳性11例；11例行小肠镜检查，9例行胶囊内镜检查，8例行小肠气钡双重对比造影，均可见阳性改变；12例行手术治疗，7例术后复发；12例行糖皮质激素治疗，8例病情缓解，4例无效；1例英夫利昔单抗治疗有效。结论　CMUSE是一种罕见的、病因不明的疾病，小肠多发浅表溃疡和肠腔狭窄是其典型表现。胶囊内镜、双气囊小肠镜对该疾病的诊断有重要意义，激素为其一线治疗，内镜下球囊扩张术开始用于治疗，其他治疗有营养支持、外科手术等。

关键词: 小肠结肠炎, 隐源性多灶性溃疡狭窄性小肠炎, 胶囊内窥镜, 糖皮质激素类, 症状和体征